Soft Tissue Masses of the Hand

Solid soft tissue masses of the hand represent a diverse group of lesions, most of which are benign. Accurate diagnosis is essential to guide management and avoid unnecessary or inappropriate surgical intervention. This review discusses solid soft tissue tumors of the hand in accordance with the 2020 World Health Organization Classification of Soft Tissue Tumors, emphasizing imaging features and clinical presentation, as well as the current European Society of Musculoskeletal Radiology guidelines from 2023 for primary imaging of soft tissue lesions. Characteristic imaging features help diagnose common entities such as lipomas, tenosynovial giant cell tumors, glomus tumors, and nerve sheath tumors. Various pseudolesions (e.g., traumatic neuromas) are also discussed. The importance of referral to specialized sarcoma centers for indeterminant or aggressive lesions is highlighted.