Gemcitabine Intravesical System Plus Cetrelimab or Cetrelimab Alone as Neoadjuvant Therapy in Muscle-Invasive Bladder Cancer: SunRISe-4 Primary Analysis and Biomarker Results
TAR-200 plus cetrelimab provided higher pCR, pOR, and 1-year RFS rates compared with cetrelimab monotherapy, supporting further investigation of the neoadjuvant combination in MIBC. utDNA and ctDNA MRD results support further investigation as biomarkers for residual local and nonlocal disease, respectively.
Authors
- Karen Urtishak (ORCID: https://orcid.org/0000-0002-5718-4424)
- Paul L. Crispen (ORCID: https://orcid.org/0000-0002-3699-6183)
- Bernardo Herrera‐Imbroda (ORCID: https://orcid.org/0000-0002-6235-4897)
- Évanguelos Xylinas (ORCID: https://orcid.org/0000-0002-9440-4895)
- Sebastiano Battaglia (ORCID: https://orcid.org/0000-0002-0809-8925)
- Benjamin Pradère (ORCID: https://orcid.org/0000-0002-7768-8558)
- Rohan Garje (ORCID: https://orcid.org/0000-0002-7244-5602)
- Sumeet Bhanvadia
- Bernadett Szabados (ORCID: https://orcid.org/0000-0002-8786-0032)
- Félix Guerrero‐Ramos (ORCID: https://orcid.org/0000-0002-0767-3465)
- Hussein Sweiti (ORCID: https://orcid.org/0000-0002-8983-6052)
- Cheri L. Peyton (ORCID: https://orcid.org/0009-0008-8778-9759)
- Cinty Gong (ORCID: https://orcid.org/0000-0003-1158-0699)
- Martin Bögemann (ORCID: https://orcid.org/0000-0002-2569-4446)
- Hind Stitou
- Andrea Necchi (ORCID: https://orcid.org/0000-0002-3007-2756)
- Neal D. Shore (ORCID: https://orcid.org/0000-0001-5767-0548)
- Sarah P. Psutka (ORCID: https://orcid.org/0000-0002-4207-7490)
- Mohamad Hasan (ORCID: https://orcid.org/0000-0002-6465-9168)
- Mark A. Preston (ORCID: https://orcid.org/0000-0003-1010-8464)
- Ja Hyeon Ku
- Cristina Sánchez de Llano
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Johnson & Johnson (United States) (US)
- University College London Hospitals NHS Foundation Trust (GB)
- Vita-Salute San Raffaele University (IT)
- Queen Mary University of London (GB)
- University of Washington (US)
- Université Paris Cité (FR)
- Seoul National University Hospital (KR)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- Fred Hutch Cancer Center (US)
- Johnson & Johnson (France) (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospital Universitario 12 De Octubre (ES)
- University Hospital Münster (DE)
- Groupe Hospitalier Diaconesses Croix Saint-Simon (FR)
- Miami Heart Research Institute (US)
- Hôpital Bichat-Claude-Bernard (FR)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Dana-Farber Brigham Cancer Center (US)
- Carolina Urologic Research Center (US)
- University College London (GB)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1200/jco-25-02382
- Citations
- 4
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.03