Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy
NaB functions as a PP2A-TFEB axis activator to restore lipophagy and ameliorate lipid accumulation in tubular epithelial cells, pointing to NaB as a promising protective agent against renal injury in DN patients.
Authors
- D. Li (ORCID: https://orcid.org/0000-0003-4084-1579)
- Liang Peng (ORCID: https://orcid.org/0000-0001-8377-0833)
- Sinan Ai
- Xin Li (ORCID: https://orcid.org/0000-0002-2122-7461)
- Jingwei Zhou (ORCID: https://orcid.org/0009-0003-1617-9447)
- Lin Wang (ORCID: https://orcid.org/0000-0001-9380-9850)
- Yuning Liu (ORCID: https://orcid.org/0000-0002-9441-9667)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-6377-3890)
- Qingqing Liu (ORCID: https://orcid.org/0000-0002-3051-8295)
- Jun Hou (ORCID: https://orcid.org/0000-0003-4089-6086)
- Yaoxian Wang
- Jiayin Tao
- Xu Wang (ORCID: https://orcid.org/0009-0009-6256-4569)
Institutions
- Beijing University of Chinese Medicine (CN)
- China-Japan Friendship Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1111/bph.70261
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00