Role of Injectable Platelet-Rich Fibrin in Periodontal Wound Healing

Injectable Platelet-Rich Fibrin has emerged as a promising therapy for regenerative periodontal treatment. This liquid formulation offers several advantages over traditional Platelet-rich fibrin and platelet-rich plasma. It exhibits a higher concentration of growth factors, including platelet-derived growth factor , insulin-like growth factor, and transforming growth factor , which are crucial for tissue regeneration and bone augmentation. Current studies have demonstrated Injectable Platelet-Rich Fibrin's regenerative potential in encouraging fibroblast movement enhancing collagen production, growth and specialization of bone-forming cells. In Addition, to its ability to reduce inflammation by lowering inflammatory substances and boosting the production of anti-inflammatory agents. Its ability to fight bacteria is linked to blood cells and antimicrobial proteins, contributing to reducing bacterial load and preventing infections. Clinical studies have reported positive outcomes regarding surgical and non-surgical periodontal treatment, tissue regeneration, reduction in pocket depth, and improvement in clinical parameters. However, further research is needed to standardize protocols, determine optimal concentrations, and assess long-term outcomes. Despite these considerations, the current evidence suggests that Injectable Platelet-Rich Fibrin holds great potential and may become a widely used therapy in regenerative periodontal procedures.