Clinical and Histological Evaluation of Sesame Oil Effect on Skin Healing in Albino Rats. In Vivo Study

Aim: this study aims to evaluate the effect of sesame oil extract on skin healing clinically by measuring wound contraction and histologically by measuring epithelial thickness and vascularization.Method: Twenty-eight male albino rats were subjected to general anesthesia, excisional wound was induced below the shoulder blades, then animals were divided into two groups:1. Control group (cont.): fourteen rats were left to heal normally2. Sesame oil group (SO): fourteen rats were treated with oil extract of sesamum indicum diary. Scarification was done in two periods: 7 and 14 days. Wounds were examined clinically and histologically.Results: wounds treated with sesame oil showed significant faster wound contraction. The epithelial thickness and vascularization were significantly higher in sesame oil group when compared with control group.Conclusion: treatment of wounds with sesame oil enhances wound healing and facilitate wound closure.