Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature

Paragangliomas (PG) are rare extra-adrenal neuroendocrine tumors that arise from neural crest-derived chromaffin cells. Metastatic involvement of the spine, particularly in the cervical region, is exceptionally uncommon. Here, we present an exceedingly rare case of a 25-year-old male with metastatic spread from a recurrent functional aortocaval paraganglioma to the cervical spine, ultimately leading to a pathological fracture, acute spinal cord injury, and neurogenic shock requiring urgent intervention.

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Journal
Cureus
Published
2025-12-03
DOI
https://doi.org/10.7759/cureus.98403
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
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0.00
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article

Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature

Mercia Gondim, Ramin Hamidi, Hanna Rupp, Arshi Kaur et al.
Cureus
Adrenal and Paraganglionic Tumors
article

Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature

Mercia Gondim, Ramin Hamidi, Hanna Rupp, Arshi Kaur, Thomas Altstadt, Sarah Danehower
article en

Abstract

Paragangliomas (PG) are rare extra-adrenal neuroendocrine tumors that arise from neural crest-derived chromaffin cells. Metastatic involvement of the spine, particularly in the cervical region, is exceptionally uncommon. Here, we present an exceedingly rare case of a 25-year-old male with metastatic spread from a recurrent functional aortocaval paraganglioma to the cervical spine, ultimately leading to a pathological fracture, acute spinal cord injury, and neurogenic shock requiring urgent intervention.

CureusVol. 17(12)
University of Louisville (US), University of Louisville Hospital (US), University of Louisville Physicians (US)
Openalex Percentile: Top 42%
Adrenal and Paraganglionic Tumors
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Acute Spinal Cord Injury in the Setting of C6 Pathologic Fracture Secondary to Metastatic Paraganglioma: A Case Report and Review of Literature — Mercia Gondim, Ramin Hamidi, et al. · Cureus (2025) | TGRS Research Map | TGRS