Histological assessment of radiotherapy-induced injury in the anal canal: an exploratory study
Radiotherapy appears to induce notable structural alterations within the anal sphincter complex, including muscle atrophy and oedema, which may contribute to post-treatment faecal incontinence. These changes seem independent of collagen fibre composition. Despite the small sample size and lack of clinical data, this study provides preliminary histological insights that warrant further investigation in larger, clinically integrated cohorts.
Authors
- Yasuko Maeda (ORCID: https://orcid.org/0000-0002-4081-4741)
- Aikaterini Leventi (ORCID: https://orcid.org/0000-0003-4975-7322)
- Dimitrios Korkolis (ORCID: https://orcid.org/0000-0003-0682-2374)
- Paul Sibbons
- Alexia Tsigka
- Rob Glynne‐Jones (ORCID: https://orcid.org/0000-0002-6742-222X)
- Εvangelia Skafida
- Morgan Moorghen (ORCID: https://orcid.org/0000-0003-0262-2674)
- C. J. Vaizey (ORCID: https://orcid.org/0000-0002-1843-059X)
- Evangelia Peponi
Institutions
- Norfolk and Norwich University Hospitals NHS Foundation Trust (GB)
- Mount Vernon Cancer Centre (GB)
- Northwick Park Institute for Medical Research (GB)
- St Savas Hospital (GR)
- Queen Elizabeth University Hospital (GB)
- St Mark's Hospital (GB)
Publication Details
- Journal
- International Journal of Colorectal Disease
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1007/s00384-025-05027-0
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00