Tenofovir alafenamide for prevention of HBV reactivation in HBsAg-negative, anti–HBc-positive patients undergoing rituximab-based chemotherapy: A multicenter randomized controlled trial
The use of preemptive TAF therapy did not reduce the risk of HBsAg reverse seroconversion; however, the findings should be interpreted with caution as the study was underpowered due to slow enrolment leading to early termination. Low-level HBV DNA elevations were not associated with HBV reactivation. Thus, close HBsAg and ALT monitoring are adequate in HBsAg-negative patients undergoing rituximab-based chemotherapy.
Authors
- Kelvin Chan (ORCID: https://orcid.org/0000-0002-2501-3057)
- Ambreen Syeda
- Matthew C. Cheung (ORCID: https://orcid.org/0000-0003-3193-5872)
- Anca Prica
- Bettina E. Hansen (ORCID: https://orcid.org/0000-0001-8307-3341)
- Harry L.A. Janssen (ORCID: https://orcid.org/0000-0003-2398-8392)
- Rena J. Buckstein (ORCID: https://orcid.org/0000-0001-9520-7386)
- Lesley Street (ORCID: https://orcid.org/0000-0003-0670-0027)
- Jordan J. Feld (ORCID: https://orcid.org/0000-0003-2640-2211)
- Michael Crump (ORCID: https://orcid.org/0000-0002-2230-8538)
- Vishal Kukreti (ORCID: https://orcid.org/0000-0002-1681-3837)
- Muhammad Atif Zahoor (ORCID: https://orcid.org/0000-0003-2302-3689)
- Grishma Hirode (ORCID: https://orcid.org/0000-0003-1530-5950)
- Lisa K. Hicks (ORCID: https://orcid.org/0000-0003-1858-7420)
- Sahar Taba Taba Vakili (ORCID: https://orcid.org/0009-0001-7422-5398)
- Patricia Disperati
- John Kuruvilla (ORCID: https://orcid.org/0000-0002-6117-320X)
- Carla S. Coffin (ORCID: https://orcid.org/0000-0002-1472-0901)
- Ahreni Saunthar
- Joshua B. Feld
Institutions
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Toronto East General Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Toronto Liver Centre (CA)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000859
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35