Multiplexed longitudinal analysis of the cellular and microbial dynamics of acute polymicrobial sepsis in mice
Collectively, the approach we describe simultaneously reduces research animal use, strengthens scientific rigor, provides a pre-clinical platform for biomarker discovery and the study of therapeutic interventions, and most importantly advances our ability to study the acute phase of sepsis that carries a high mortality rate and is difficult to prospectively study in humans.
Authors
- Amy Jolly (ORCID: https://orcid.org/0000-0002-7413-9772)
- Colin E. Evans (ORCID: https://orcid.org/0000-0002-9251-357X)
- Tori E. Peacock
- Jason L. Kubinak (ORCID: https://orcid.org/0000-0001-9866-8225)
- Sylvia L. F. Pender (ORCID: https://orcid.org/0000-0001-6332-0333)
- Kandy T. Velázquez (ORCID: https://orcid.org/0000-0003-2427-165X)
- J. Hunter Cox (ORCID: https://orcid.org/0009-0001-8771-9733)
- Ahmed Dawood Mohammed (ORCID: https://orcid.org/0000-0002-2504-8583)
- Jay D. Potts (ORCID: https://orcid.org/0000-0003-4932-9643)
- Norma Frizzell (ORCID: https://orcid.org/0000-0002-5080-4176)
- Ryan A. W. Ball
- Karl M. Johnson
- Angela Murphy
- Abhinav R. Cheedipudi
Institutions
- University of South Carolina (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1682451
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- University of South Carolina
- National Institutes of Health
- School of Medicine, University of South Carolina
- National Institute of General Medical Sciences