Keller/eGFR ratio as a simple and useful tool to make a first differentiation between renal aging and chronic nephropathy in large populations

The Keller/eGFR ratio represents a practical, low-cost, and easily applicable index for the first-line screening of kidney function in older adults. When combined with biochemical and imaging markers, it enhances diagnostic accuracy and helps avoid excessive medicalization related to CKD misclassification. Wider implementation in population studies could improve epidemiological stratification and resource allocation in nephrology care.