Association of polymorphisms in 17 loci with primary open-angle glaucoma in Chinese and Japanese
This study confirms <i>AFAP1</i> rs938604, <i>FNDC3B</i> rs62283813, <i>GAS7</i> rs9913911 and <i>SPRED2</i> rs4414666 as HTG-specific loci in Chinese and Japanese populations. These findings provide new insights into the genetic architecture of POAG, highlighting distinct molecular mechanisms between HTG and NTG subtypes.
Authors
- Clement Chee Yung Tham (ORCID: https://orcid.org/0000-0003-4407-6907)
- Jason C. S. Yam (ORCID: https://orcid.org/0000-0002-2156-1486)
- Shinichi Usui (ORCID: https://orcid.org/0000-0002-9671-9866)
- Poemen P. Chan (ORCID: https://orcid.org/0000-0003-4298-8806)
- Li Jia Chen (ORCID: https://orcid.org/0000-0003-3500-5840)
- Rumi Kawashima
- Alvin Lerrmann Young (ORCID: https://orcid.org/0000-0002-4365-3218)
- Chukai Huang (ORCID: https://orcid.org/0000-0002-3219-1329)
- Anni Ling (ORCID: https://orcid.org/0000-0003-4479-1003)
- Chi Pui Pang (ORCID: https://orcid.org/0000-0002-7764-6382)
- Mingzhi Zhang (ORCID: https://orcid.org/0000-0001-9032-7274)
- Kenji Matsushita (ORCID: https://orcid.org/0000-0002-0418-6696)
- Kohji Nishida (ORCID: https://orcid.org/0000-0001-8838-7593)
- Shu Ying Chen
- Motokazu Tsujikawa (ORCID: https://orcid.org/0009-0008-1084-7340)
- Pancy O. S. Tam
Institutions
- Chinese University of Hong Kong (HK)
- Hong Kong Eye Hospital (CN)
- Shantou University (CN)
- Prince of Wales Hospital (CN)
- The University of Osaka (JP)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1136/bjo-2025-328041
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00