Immunomodulation of UVB-induced regulatory T cells prevents the establishment of squamous cell carcinoma
Our findings show that the manipulation of UV-induced Tregs prevents early cSCC establishment. Thus, strategies aimed at modulating Treg function or abundance in the skin may represent a feasible therapeutic avenue for the prevention of cSCC tumor emergence in patients.
Authors
- Amina Ashraf (ORCID: https://orcid.org/0009-0009-8486-3893)
- Joseph Yunis (ORCID: https://orcid.org/0000-0002-0272-0605)
- Jazmina L. Gonzalez Cruz (ORCID: https://orcid.org/0000-0003-2671-7408)
- James W. Wells (ORCID: https://orcid.org/0000-0002-9618-6940)
- Shoaib Anwaar (ORCID: https://orcid.org/0000-0001-8711-0218)
- Sarah Jahfali
Institutions
- Queensland University of Technology (AU)
- The University of Queensland (AU)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-013118
- Citations
- 1
- Primary Topic
- Skin Protection and Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.00