Evaluation of multi-antigen targeting ADCC strategies in pediatric BCP-ALL
CD24 therefore emerged as an effective target in BCP-ALL, and the combination of CD24 and CD123 as a potential effective double-targeting strategy. The combination of different recognition modalities (eg, a CAR and CD16) should be tested to determine whether it provides synergistic cytotoxic activity in triple targeting.
Authors
- Audrey Grain (ORCID: https://orcid.org/0000-0003-1547-8229)
- Caroline Thomas (ORCID: https://orcid.org/0000-0002-3939-9317)
- Elodie Guiet
- Marion Eveillard (ORCID: https://orcid.org/0000-0001-7206-5135)
- Fanny Rialland (ORCID: https://orcid.org/0000-0002-3136-6270)
- Baptiste Le Calvez (ORCID: https://orcid.org/0000-0001-5148-3792)
- Emmanuel Scotet (ORCID: https://orcid.org/0000-0001-8010-9556)
- Béatrice Clemenceau (ORCID: https://orcid.org/0000-0001-5305-4502)
- Jocelyn Ollier (ORCID: https://orcid.org/0000-0002-2723-1103)
- Margaux Camuset
- Marie‐Laure Couec
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Centre d'Investigation Clinique de Nantes (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-012552
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique