Maternal Obesity Leads to Muscle Dysfunction via <i>H19</i> -Mediated Programming of Insulin-Like Growth Factor 2 Signaling
H19-mediated epigenetic modifications alter Igf2 promoter activity, leading to persistent Igf2 suppression in maternal obesity (MO) offspring, causing long-term muscle dysfunction. MO increases H19 expression and enhances EZH2 recruitment and H3K27me3 deposition in the Igf2 P3 promoter, leading to higher DNA methylation. H19-EZH2 axis provides a potential therapeutic target for mitigating MO-induced muscle dysfunction and improving offspring metabolic health.
Authors
- Min Du (ORCID: https://orcid.org/0000-0002-7232-072X)
- Li Wei Chen (ORCID: https://orcid.org/0000-0003-2878-8613)
- Jeanene M. de Avila (ORCID: https://orcid.org/0000-0003-3947-7992)
- Zhongyun Kou (ORCID: https://orcid.org/0000-0003-2369-049X)
- Xinrui Li (ORCID: https://orcid.org/0009-0002-7590-1543)
- MohammadSowkat Hossain
- Mei-Jun Zhu
- S Islam (ORCID: https://orcid.org/0000-0002-2167-6427)
Institutions
- Washington State University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-12-03
- DOI
- https://doi.org/10.2337/db25-0271
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00