Salvianolic acid B targets MST1/2-YAP axis to drive phospho-Smad3L/C conversion against hepatocarcinogenesis
Sal B impedes HCC by targeting MST1/2-YAP axis to drive pSmad3L/C conversion. This work identifies the first phytochemical strategy against HCC that reprograms YAP/pSmad3C-L interactions, positioning MST1/2-YAP-driven phospho-Smad3 conversion as a promising therapeutic axis.
Authors
- Jingqi Zhou (ORCID: https://orcid.org/0000-0002-9961-199X)
- Yanyan Xu (ORCID: https://orcid.org/0000-0002-8152-7423)
- Siyi He (ORCID: https://orcid.org/0000-0001-7812-997X)
- Yongfang Gong
- Seung Hyeok Han (ORCID: https://orcid.org/0000-0001-7923-5635)
- Wenjing Xu (ORCID: https://orcid.org/0000-0002-1423-6271)
- Yan Yang (ORCID: https://orcid.org/0000-0002-4183-826X)
- Changfeng Xue (ORCID: https://orcid.org/0000-0002-2905-5377)
- Yuqi Dang
Institutions
- Anhui Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.phymed.2025.157655
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00