A UK-wide analysis of 2265 patients receiving a reversal agent for direct oral anticoagulant–associated bleeding

Reversal agents were generally used in patients with clinical evidence of major bleeding but were administered long after the last anticoagulant dose. In gastrointestinal bleeding, andexanet alfa was associated with a higher thrombotic risk than 4F-PCC.

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Publication Details

Journal
Journal of Thrombosis and Haemostasis
Published
2025-12-03
DOI
https://doi.org/10.1016/j.jtha.2025.11.003
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

A UK-wide analysis of 2265 patients receiving a reversal agent for direct oral anticoagulant–associated bleeding

Bright Nwatamole, Crystal Watson, A B Barua, S Ashwini et al.
Journal of Thrombosis and Haemostasis
Atrial Fibrillation Management and Outcomes
article

A UK-wide analysis of 2265 patients receiving a reversal agent for direct oral anticoagulant–associated bleeding

Bright Nwatamole, Crystal Watson, A B Barua, S Ashwini, Hajer Oun, Geraint P. Williams, Carol A. Hickman, Lauren Ellis, Komal Naeem, A. Davì, Maya Raj, Joanna B. Fawcett, Taran K Nandra, Olga Tsiamita, Paul Stimpson, Nomathamsanqa Tshuma, Pyae Lwin, Najmul Hasan, Tatiana Christmas, Anjali Shrestha, B. Recaldin, Matthew Truman, Fatima Shakkak, Elizabeth Steven, Sai H. Bhatte, Julia Rowley Anderson, J. Wylie, Suzanne Docherty, Rachel Wright, Mevish Ul-haq, Annie Curtis, Shahzad Anjum, Eleanor Wong, Ankit Patel, Hui‐Li Wong, Bauke M. de Jong, Rhian Fuge, Astrid Etherington, Loredana Gabriela Mihailescu, Nkemdirim Jacob, Herng Mak, Hannah Giles, Daniel W. Rogalsky, Nicola Curry, Richard Karim, Ipek Cakmak, Rimsha Khan, Sanjay Chattree, Mutiu Ademayowa Adeyemo, N.M.T.C. Jayasekara, Karthik Basker, Georgina Naylor, David Simcox, Nikola Tom, Thura Win Htut, Michala E. Pettitt, Tin Aung, Jack Illingworth, Laura L. Watkins, K. E. 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Beattie, J. C. Phillips, Bernard Maybury, Maryam Subhan, Jahanzeb Khawaja, RosalineYumumkahKanjo Cumber, Maheen Ahsan, James Morgan, Kerry A. Morrison, Sajida Kazi, C. F. Drury, Milad Ghanikolahloo, Michael Joffe, Maung Mg Htwe, Zin Thawdar Oo, Mishal Iqbal, Rebecca Sarsam, James L. Riley, Jack Murrell, Jireh Ann L. Batac, Giorgio Bartalucci, Portia Eardley, Muzna Aquil, Malahat Saeed, Jackie Ruell, Philip Robson, Henry Crosland, Karyn Longmuir, Ian Devanny, Francesca Leonforte, Anke Meess, Laura Munglani, Timothy Ebsworth, Sarah Lewis, Laura James, Jasmine Makker, Fatima Noor, Benjamin Gray, Matthew Carter, Tao Han, Mohammed Khan, Natalie Martin, A. Page, M. Harrison, Erica Harris, Nithya Krishnan, Rebecca Shaw, Thomas A. A. Skinner, K De Rivera, Sarah Mohamed, Shalini Solanki, Luis Gutierrez, Victoria Greer, Xavier Peer, Juan Tan, Lorna Cain, Scott Jenkins, J. Stuart Wolf, K. Moss, Lisa Robinson, Rhona Maclean, Emily Jones, F Patel, Joanne Hoyle, V. Stanley, S. P. 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article en

Abstract

Reversal agents were generally used in patients with clinical evidence of major bleeding but were administered long after the last anticoagulant dose. In gastrointestinal bleeding, andexanet alfa was associated with a higher thrombotic risk than 4F-PCC.

Journal of Thrombosis and HaemostasisVol. 24(3)
University of Birmingham (GB)
AstraZeneca, CSL Behring, National Institute for Health and Care Research, British Heart Foundation
Openalex Percentile: Top 45%
Atrial Fibrillation Management and Outcomes
DOIOpen Access PDFOpenAlex
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