Genetic risk factors for MASLD/MASH and cardiovascular disease in elderly individuals
Our findings reveal that specific MASLD/MASH-associated genetic variants influence FIB-4 scores and are linked to cardiovascular and mortality outcomes in an elderly population. These results suggest that liver fibrosis may reflect not only hepatic injury, but also broader systemic vulnerability driven by genetic predisposition. Incorporating genetic risk profiles may improve stratification for both liver and cardiometabolic disease.
Authors
- J. Wouter Jukema (ORCID: https://orcid.org/0000-0002-3246-8359)
- Vivian de Jong (ORCID: https://orcid.org/0000-0002-4692-479X)
- Willy Theel (ORCID: https://orcid.org/0000-0003-3639-0963)
- Stella Trompet (ORCID: https://orcid.org/0000-0001-5006-0528)
- Manuel Castro Cabezas (ORCID: https://orcid.org/0009-0009-5164-2082)
- Diederick E. Grobbee
Institutions
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Sint Franciscus Gasthuis (NL)
- Leidsche Rijn Julius Health Centers (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.aohep.2025.102170
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00