NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced <i>TP53</i> mutant gastroesophageal cancer

This novel combination of ATR inhibitor berzosertib with irinotecan did not lead to objective responses in patients with TP53-mutated, advanced gastroesophageal adenocarcinoma. The combination regimen was well tolerated without unexpected adverse events. This trial was registered with ClinicalTrials.gov (NCT03641313).

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Publication Details

Journal
The Oncologist
Published
2025-12-01
DOI
https://doi.org/10.1093/oncolo/oyaf400
Primary Topic
Cancer-related Molecular Pathways
Type
article
Field-Weighted Citation Impact
0.00

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article

NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced TP53 mutant gastroesophageal cancer

Bella S. Guerrouahen, Katherine V. Ferry‐Galow, Margaret C. Wheless, Farshid Dayyani et al.
The Oncologist
Cancer-related Molecular Pathways
article

NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced TP53 mutant gastroesophageal cancer

Bella S. Guerrouahen, Katherine V. Ferry‐Galow, Margaret C. Wheless, Farshid Dayyani, Alejandro Contreras, Jordan Berlin, Gregory D. Ayers, Vaia Florou, Anwaar Saeed, Steven Gore, Heloisa P. Soares, Satya Das, Shannon Stockton, Liqing Li, Edward Kim, Ning Jin, George Yacoub
article en

Abstract

This novel combination of ATR inhibitor berzosertib with irinotecan did not lead to objective responses in patients with TP53-mutated, advanced gastroesophageal adenocarcinoma. The combination regimen was well tolerated without unexpected adverse events. This trial was registered with ClinicalTrials.gov (NCT03641313).

The OncologistVol. 30(12)
Atrium Health Wake Forest Baptist (US), The University of Texas MD Anderson Cancer Center (US), Huntsman Cancer Institute (US), University of California, Irvine Medical Center (US), Therapeutics Clinical Research (US), Florida Cancer Specialists & Research Institute (US), UPMC Hillman Cancer Center (US), Frederick National Laboratory for Cancer Research (US), University of Pittsburgh Medical Center (US), National Cancer Institute (US), University of California Davis Medical Center (US), The Ohio State University (US), Vanderbilt University Medical Center (US)
Merck KGaA, National Institutes of Health, EMD Serono, National Cancer Institute
Openalex Percentile: Top 47%
Cancer-related Molecular Pathways
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