NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced <i>TP53</i> mutant gastroesophageal cancer
This novel combination of ATR inhibitor berzosertib with irinotecan did not lead to objective responses in patients with TP53-mutated, advanced gastroesophageal adenocarcinoma. The combination regimen was well tolerated without unexpected adverse events. This trial was registered with ClinicalTrials.gov (NCT03641313).
Authors
- Bella S. Guerrouahen (ORCID: https://orcid.org/0000-0003-4124-4389)
- Katherine V. Ferry‐Galow
- Margaret C. Wheless
- Farshid Dayyani (ORCID: https://orcid.org/0000-0002-4970-5189)
- Alejandro Contreras (ORCID: https://orcid.org/0000-0001-6668-823X)
- Jordan Berlin (ORCID: https://orcid.org/0000-0001-7571-2385)
- Gregory D. Ayers
- Vaia Florou (ORCID: https://orcid.org/0000-0001-5558-753X)
- Anwaar Saeed (ORCID: https://orcid.org/0000-0001-8024-9401)
- Steven Gore (ORCID: https://orcid.org/0009-0004-5227-4502)
- Heloisa P. Soares (ORCID: https://orcid.org/0000-0002-5185-2583)
- Satya Das (ORCID: https://orcid.org/0000-0002-7625-1039)
- Shannon Stockton (ORCID: https://orcid.org/0000-0003-2799-663X)
- Liqing Li (ORCID: https://orcid.org/0000-0001-8297-309X)
- Edward Kim (ORCID: https://orcid.org/0000-0002-8660-7465)
- Ning Jin
- George Yacoub
Institutions
- Atrium Health Wake Forest Baptist (US)
- The University of Texas MD Anderson Cancer Center (US)
- Huntsman Cancer Institute (US)
- University of California, Irvine Medical Center (US)
- Therapeutics Clinical Research (US)
- Florida Cancer Specialists & Research Institute (US)
- UPMC Hillman Cancer Center (US)
- Frederick National Laboratory for Cancer Research (US)
- University of Pittsburgh Medical Center (US)
- National Cancer Institute (US)
- University of California Davis Medical Center (US)
- The Ohio State University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1093/oncolo/oyaf400
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Merck KGaA
- National Institutes of Health
- EMD Serono
- National Cancer Institute