Epicardial adipose tissue produces L-3-hydroxybutyrate in advanced heart failure: direct analysis of fat metabolic remodeling
HF progression drives major, depot-specific metabolic remodeling in adipose tissue. In advanced HF, EAT shows impaired fatty acid oxidation and enhanced local production of L-3-hydroxybutyrate in the vicinity of myocardium, highlighting the close metabolic cooperation in nutrient supply between EAT and the heart muscle through the coronary circulation.
Authors
- Martin Haluzı́k (ORCID: https://orcid.org/0000-0002-0201-6888)
- Barbora Judita Kasperová (ORCID: https://orcid.org/0000-0003-4578-1093)
- Kateřina Adamcová (ORCID: https://orcid.org/0000-0002-7220-5924)
- Martin Riecan (ORCID: https://orcid.org/0000-0001-6251-1277)
- Tomáš Čajka (ORCID: https://orcid.org/0000-0002-9728-3355)
- Petra Janovská (ORCID: https://orcid.org/0000-0002-6154-2175)
- Peter Ivák (ORCID: https://orcid.org/0000-0002-1803-604X)
- Ondřej Kuda (ORCID: https://orcid.org/0000-0001-7034-4536)
- Michaela Vondráčková (ORCID: https://orcid.org/0009-0005-6434-0201)
- Ivan Netuka (ORCID: https://orcid.org/0000-0002-1567-7036)
- Katerina Kroupova
- Soňa Štemberková Hubáčková
- Daniel Hlaváček (ORCID: https://orcid.org/0000-0001-8453-1666)
- Vojtěch Melenovský (ORCID: https://orcid.org/0000-0001-8921-7078)
- Eliška Haasová
- Ján Kopecký (ORCID: https://orcid.org/0000-0001-8072-2035)
- Miloš Mráz (ORCID: https://orcid.org/0000-0001-5322-4612)
Institutions
- Czech Academy of Sciences (CZ)
- Institute of Microbiology (BY)
- Institute of Clinical and Experimental Medicine (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- Metabolism
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.metabol.2025.156465
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- European Commission