Transforming healthcare with large language models: Current applications, challenges, and future directions—a literature review

Abstract AI‐based large language models (LLMs) have gradually made their way into various fields, transforming industries and changing the way we solve problems. LLMs have great potential in healthcare, where they can share the burden of data management, retrieval, and decision‐making. The objective of this paper is to analyze the pivotal role of LLMs in healthcare by underscoring its current applications in healthcare, its advantages and limitations, its real‐world implementations of LLMs, along with expectations for the future. LLMs can be of service to the physicians by aiding diagnosis and management and device personalized therapeutic plans for the patients. Currently, LLMs are serving a purpose in healthcare by facilitating patient communication and education, medical documentation, and dissecting medical literature although each come its own challenges. Its advanced efficiency, accessibility, patient centric care, and predictive power is what makes it a powerful tool in healthcare. However, certain concerns such as data privacy and security, bias, regulatory issues, and technical challenges greatly limits its integration into the healthcare system. There can be further research done on exploring advanced training techniques as well as on appropriate regulatory models. Despite these limitations, it has the potential to revolutionize healthcare delivery.

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Publication Details

Journal
Journal of intelligent medicine.
Published
2025-12-03
DOI
https://doi.org/10.1002/jim4.70015
Primary Topic
Artificial Intelligence in Healthcare and Education
Type
article
Field-Weighted Citation Impact
0.00
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article

Transforming healthcare with large language models: Current applications, challenges, and future directions—a literature review

Muhammad Umar, Noor ul Ain, Laiba Shamim, Imshaal Musharaf et al.
Journal of intelligent medicine.
Artificial Intelligence in Healthcare and Education
article

Transforming healthcare with large language models: Current applications, challenges, and future directions—a literature review

Muhammad Umar, Noor ul Ain, Laiba Shamim, Imshaal Musharaf, Osama Ahmad, Muhammad Saeed, S Y Iftikhar, Muhammad Umar Ahsan, Soofia Ahmed, Lamea Bint Sabhan, Rabia Hafsa, Vanessa Ali
article en

Abstract

Abstract AI‐based large language models (LLMs) have gradually made their way into various fields, transforming industries and changing the way we solve problems. LLMs have great potential in healthcare, where they can share the burden of data management, retrieval, and decision‐making. The objective of this paper is to analyze the pivotal role of LLMs in healthcare by underscoring its current applications in healthcare, its advantages and limitations, its real‐world implementations of LLMs, along with expectations for the future. LLMs can be of service to the physicians by aiding diagnosis and management and device personalized therapeutic plans for the patients. Currently, LLMs are serving a purpose in healthcare by facilitating patient communication and education, medical documentation, and dissecting medical literature although each come its own challenges. Its advanced efficiency, accessibility, patient centric care, and predictive power is what makes it a powerful tool in healthcare. However, certain concerns such as data privacy and security, bias, regulatory issues, and technical challenges greatly limits its integration into the healthcare system. There can be further research done on exploring advanced training techniques as well as on appropriate regulatory models. Despite these limitations, it has the potential to revolutionize healthcare delivery.

Journal of intelligent medicine.Vol. 3(1)
Khyber Medical College (PK), Nishtar Medical College and Hospital (PK), Jinnah Sindh Medical University (PK), Ghazi University (PK), Shaikh Zayed Postgraduate Medical Institute (PK), Shah Abdul Latif University (PK), Dhaka Medical College and Hospital (BD)
Openalex Percentile: Top 68%
Artificial Intelligence in Healthcare and Education
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