Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy
This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy, such as Cerebrolysin, is likely to further improve patient outcomes. Beyond its established neurorecovery benefits, recent data indicate that Cerebrolysin also offers protection to the neurovascular unit and the blood-brain barrier. This paper introduces the CErebrolysin in RECanalization And Perfusion (CERECAP) program, a collaborative initiative of independent academic investigations exploring the favorable trends of Cerebrolysin in reperfusion. The CERECAP program has generated compelling data demonstrating Cerebrolysin's alignment with current AIS reperfusion therapy concepts, particularly its role in early intervention targeting multiple pathways. We review these studies and discuss the critical need to clearly define the patient population that benefit most from adjunctive Cerebrolysin therapy in AIS.
Authors
- Roni Eichel (ORCID: https://orcid.org/0009-0007-9181-901X)
- Marissa Ong (ORCID: https://orcid.org/0009-0003-7634-0220)
- S. Michalak (ORCID: https://orcid.org/0000-0002-5602-4306)
- Marina Roje Bedeković (ORCID: https://orcid.org/0000-0002-3469-1589)
- Zdravka Poljaković (ORCID: https://orcid.org/0000-0002-7216-6478)
- Д. Р. Хасанова (ORCID: https://orcid.org/0000-0002-8825-2346)
- Fernando Góngora‐Rivera (ORCID: https://orcid.org/0000-0003-1224-3942)
- Aurauma Chutinet (ORCID: https://orcid.org/0000-0002-9762-5562)
- Peter Quitasol
- Mikhail N. Kalinin (ORCID: https://orcid.org/0000-0002-3664-6888)
- Klaudyna Kojder
- Steven R. Zeiler (ORCID: https://orcid.org/0000-0002-5430-446X)
- Jacek Staszewski (ORCID: https://orcid.org/0000-0002-5588-9148)
- Ahmed Elbassiouny (ORCID: https://orcid.org/0000-0002-6945-1470)
- Marc Ribó (ORCID: https://orcid.org/0000-0001-9242-043X)
- Chien-Hung Chang (ORCID: https://orcid.org/0000-0002-9274-9603)
- Minwoo Lee (ORCID: https://orcid.org/0000-0001-8474-5744)
- Natan M. Bornstein (ORCID: https://orcid.org/0000-0003-0195-7827)
- Alexander Tsiskaridse
Institutions
- Tbilisi State University (GE)
- University of Szczecin (PL)
- Ain Shams University (EG)
- Poznan University of Medical Sciences (PL)
- Hebron University (PS)
- National Academy of Medicine (US)
- Johns Hopkins University (US)
- Hallym University (KR)
- Chulalongkorn University (TH)
- Kazan State Medical University (RU)
- Johns Hopkins Medicine (US)
- Shaare Zedek Medical Center (IL)
- Chang Gung Memorial Hospital (TW)
- University of Baguio (PH)
- Sacred Heart Hospital (NG)
- East Avenue Medical Center (PH)
- Hrvatski zavod za javno zdravstvo (HR)
- Linkou Chang Gung Memorial Hospital (TW)
- Sisters of Charity Hospital (HR)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Dr José Eleuterio Gonzalez (MX)
- State Autonomous Institution of Health Interregional Clinical Diagnostic Center (RU)
- Tbilisi State Medical University (GE)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108515
- Citations
- 1
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84