Modulation of the tumor microenvironment through BMAL1-LHX8 axis augments the sensitivity of ameloblastoma to vemurafenib
Our findings reveal the role of the BMAL1-LHX8 axis in underlying AMF-mediated drug resistance in AM, and propose that the molecular clock modulation in tumor-stroma crosstalk represents a potential therapeutic avenue for ameloblastoma.
Authors
- Jin Hoo Park
- Young‐Soo Jung (ORCID: https://orcid.org/0000-0001-5831-6508)
- Hyun‐Yi Kim
- Han‐Sung Jung (ORCID: https://orcid.org/0000-0003-2795-531X)
- Shujin Li (ORCID: https://orcid.org/0000-0002-8818-5411)
- Takashi Muramatsu (ORCID: https://orcid.org/0000-0001-8564-8508)
- Jun‐Young Kim (ORCID: https://orcid.org/0000-0002-6596-6135)
- Eunjung Kim (ORCID: https://orcid.org/0000-0003-0895-8582)
Institutions
- Tokyo Dental College (JP)
- Yonsei University (KR)
- Stomatology Hospital (CN)
- Yonsei University College of Dentistry
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.069
- Primary Topic
- Oral and Maxillofacial Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00