Tolerance but No Spontaneous Withdrawal Following Repeated THC Injections in Male and Female Rats

These data suggest that spontaneous THC withdrawal in male and female rats is mild at best despite profound locomotor suppression and tolerance to repeated injections. The lack of spontaneous THC withdrawal contrasts sharply with the pronounced changes in wheel running produced by opioid withdrawal.

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Publication Details

Journal
Cannabis and Cannabinoid Research
Published
2025-12-03
DOI
https://doi.org/10.1177/25785125251404395
Primary Topic
Neurotransmitter Receptor Influence on Behavior
Type
article
Field-Weighted Citation Impact
0.00
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article

Tolerance but No Spontaneous Withdrawal Following Repeated THC Injections in Male and Female Rats

William H. Grimes, C. E. Poling, A Calvert, Michael M. Morgan et al.
Cannabis and Cannabinoid Research
Neurotransmitter Receptor Influence on Behavior
article

Tolerance but No Spontaneous Withdrawal Following Repeated THC Injections in Male and Female Rats

William H. Grimes, C. E. Poling, A Calvert, Michael M. Morgan, Carol A. Hickey
article en

Abstract

These data suggest that spontaneous THC withdrawal in male and female rats is mild at best despite profound locomotor suppression and tolerance to repeated injections. The lack of spontaneous THC withdrawal contrasts sharply with the pronounced changes in wheel running produced by opioid withdrawal.

Cannabis and Cannabinoid ResearchVol. 11(1)
Washington State University Vancouver (US)
Openalex Percentile: Top 59%
Neurotransmitter Receptor Influence on Behavior
DOISourceOpenAlex
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Tolerance but No Spontaneous Withdrawal Following Repeated THC Injections in Male and Female Rats — William H. Grimes, C. E. Poling, et al. · Cannabis and Cannabinoid Research (2025) | TGRS Research Map | TGRS