Breaking the Scalability Barrier: Diversifiable Pd-Catalyzed Domino Reaction En Route to Dibenzo[ <i>b,d</i> ]azepines
Herein, we present an efficient synthesis of diverse dibenzo[<i>b,d</i>]azepines in high yields via Pd-catalyzed domino reactions of 2,2'-dihalobiphenyls with <i>N</i>-allyl alkylamines. The key to this success is in situ generation of a five-membered, chelated Pd(IV) species via the subsequent activation of two C-Br bonds at the initial step, supported by control experiments, density functional theory, and machine learning calculations.
Authors
- Zhen Chen (ORCID: https://orcid.org/0000-0002-6289-4332)
- Weiwei Fang (ORCID: https://orcid.org/0000-0002-2701-5216)
- Pavlo O. Dral (ORCID: https://orcid.org/0000-0002-2975-9876)
- Lingchao Cai (ORCID: https://orcid.org/0000-0001-9038-2724)
- Ruoqian Fan
- Yaohuang Huang
Institutions
- Nanjing Forestry University (CN)
- Xiamen University (CN)
- Nicolaus Copernicus University (PL)
- Institute of Physics (PL)
- Koito Manufacturing (Japan) (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1021/acs.orglett.5c04342
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00