Subtractive genomic approach to uncover novel drug targets in Salmonella typhimurium and computational screening of food-based polyphenols as inhibitors

This study validates MurG as a druggable target in <i>S. typhimurium</i> and identifies 6-prenylnaringenin as a potent inhibitor. With computational metrics superior to ciprofloxacin, 6-prenylnaringenin is a promising lead compound for developing new anti-Salmonella therapeutics. Future experimental validation is required to confirm these <i>in silico</i> findings.