The European Nucleotide Archive in 2025
The European Nucleotide Archive (ENA; https://www.ebi.ac.uk/ena), hosted at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI), remains a global, open-access platform for the submission, archiving, dissemination, and reuse of nucleotide sequence data. In 2025, ENA continues to advance its mission of fostering FAIR (findable, accessible, interoperable, reusable) data principles through innovations in interoperability, scalability, and global engagement, providing infrastructure for a rapidly growing volume of data across diverse domains. This article highlights the key developments in 2025, including the progress of the technical transformation, enhanced support for large-scale biodiversity projects, and the implementation of the International Nucleotide Sequence Database Collaboration Global Participation Initiative. We also discuss infrastructure enhancements to handle exponential data growth and improve user experiences and data discovery.
Authors
- David Yu Yuan (ORCID: https://orcid.org/0000-0003-1075-1628)
- Bastin Tony
- W. Brewer Peter
- Ankur Lathi (ORCID: https://orcid.org/0000-0002-7333-8550)
- Awais Athar (ORCID: https://orcid.org/0000-0002-8873-8821)
- Isuru Liyanage (ORCID: https://orcid.org/0000-0002-4839-5158)
- Muhammad Hamza (ORCID: https://orcid.org/0000-0001-8263-2279)
- Joana Paupério (ORCID: https://orcid.org/0000-0003-2569-0768)
- Manish Kumar (ORCID: https://orcid.org/0000-0001-5947-7469)
- Colman O’Cathail (ORCID: https://orcid.org/0000-0002-0151-0657)
- Guy Cochrane (ORCID: https://orcid.org/0000-0001-7954-7057)
- D. Rajkumar
- Waheed K. Zahra (ORCID: https://orcid.org/0000-0002-6448-6877)
- Aggarwal Alisha
- Jeena Rajan (ORCID: https://orcid.org/0000-0002-3613-0013)
- Pesant Stephane
- Tutis Iva (ORCID: https://orcid.org/0009-0005-5908-5891)
- Ventouratou Marianna
- Vijayaraja Senthilnathan
- Khen Amnon
- Paz Ruben
- Rahman Nadim
- Sarkans Ugis
- Gupta Dipayan
- Ihsan Maira
- Kadhirvelu Vishnukumar
- Meszaros Lili
- Ivanov Eugene
Institutions
- European Bioinformatics Institute (GB)
- Bioinformatics Institute (RU)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1093/nar/gkaf1295
- Citations
- 2
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.61