Electrospun bioactive polymer biomaterials enriched with collagen and platelet-rich plasma as a platform for in vitro chondrogenic differentiation of human mesenchymal stem cells
Furthermore, the observations revealed the presence of two critical markers of cartilage differentiation: namely, actin cytoskeletal reorganization and depolymerization. The presented findings highlight the potential of bioactive PLA fibrous mats enriched with PRP and collagen I as promising platforms for cartilage tissue regeneration. The combination of electrospinning techniques enables tailored fiber structures that support chondrogenesis, offering a potential alternative for tissue engineering applications.
Authors
- Ewa Kijeńska‐Gawrońska (ORCID: https://orcid.org/0000-0002-2614-2838)
- Paulina Trzaskowska (ORCID: https://orcid.org/0000-0001-9242-6049)
- Kamil Kopeć (ORCID: https://orcid.org/0000-0003-3448-1386)
- Wojciech Święszkowski (ORCID: https://orcid.org/0000-0003-4216-9974)
- Tomasz Ciach (ORCID: https://orcid.org/0000-0002-8726-8944)
- Piotr Wieciński
- Ewa Rybak (ORCID: https://orcid.org/0000-0001-8074-8438)
Institutions
- Warsaw University of Technology (PL)
- Division of Materials Science and Engineering (AU)
- Advanced Materials and Technologies (Slovenia) (SI)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.3389/fbioe.2025.1629912
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Politechnika Warszawska