No Ergogenic Effect of Caffeine or Sodium Bicarbonate on Resistance Exercise Performance: A Double-Blind Crossover Study with Sex-Based Analysis

Caffeine, a nervous system stimulant, and sodium bicarbonate, a metabolic buffer, have been shown to improve performance in high-intensity, particularly aerobic, exercises. This randomized, double-blind, placebo-controlled, crossover study compared the acute effects of caffeine and sodium bicarbonate on chest press (CP) and knee extension (KE) performance. Twelve resistance-trained young adults (seven females) completed three testing sessions during which they consumed caffeine (0.003 g/kg of body weight), sodium bicarbonate (0.3 g/kg of body weight), or placebo at 120, 90, and 60 min prior to testing. Testing consisted of six sets of CP and KE for as many repetitions as possible at 70% of the participants' 1-repetition maximum load. A 60 s recovery between sets, and 2 min recovery was allocated between exercises. Blood pressure and blood lactate were recorded pre-, mid-, and post-test. Heart rate, ratings of perceived exertion (RPE), repetitions, and electromyography (EMG) were recorded for every set. No significant differences were found under any condition for RPE, EMG, and KE repetitions. A main effect for groups revealed was increased CP repetitions with sodium bicarbonate (7.42; 95%CI: 6.8-7.9) versus caffeine (6.7; 95%CI: 6.1-7.3) and control (7.1; 95%CI: 6.4-7.6) conditions. However, post hoc analysis did not achieve significance. Diastolic blood pressure was significantly (<i>p</i> = 0.03) greater with caffeine (79.2 mmHg; 95%CI: 74.6-83.7) than with sodium bicarbonate (72.7 mmHg; 95%CI: 67.5-77.9) and control (74.5 mmHg; 95%CI: 71.7-77.3). Females had significantly lower blood lactate measurements, higher CP repetitions, and lower heart rates, despite similar resting heart rates between the sexes. Caffeine (0.003 g/kg) or sodium bicarbonate (0.3 g/kg) did not provide acute ergogenic effects on CP or KE strength endurance (six sets of CP and KE at 70% 1-repetition maximum load) performance in young adult women and men.