ERRATUM Antioxidant, Hepatoprotective and Toxicological Assessment of Dillenia ovata in Mice

Dillenia ovata Wall. (DOW), collected from An Giang province, Vietnam, has been used traditionally in folk medicine. This study investigated the antioxidant and hepatoprotective potential of the crude ethanolic extract of Dillenia ovata. The antioxidant potential of the extract was evaluated in vitro using DPPH radical scavenging, reducing power (RP), and total antioxidant capacity (TAC) tests. Hepatoprotective effects were assessed in a Carbon tetrachloride (CCl₄)–induced liver injury model, where mice received Dillenia ovata extract at doses of 100, 200, or 400 mg/kg for 28 days. Biochemical analyses revealed that Dillenia ovata, especially at 400mg/kg, significantly attenuated CCl₄–induced elevations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA), while restoring glutathione (GSH) levels. Histopathological examination further confirmed the protective effect by showing improved hepatic architecture. In vivo safety evaluation showed no signs of toxicity in both acute and sub-chronic studies in mice. These findings suggest that Dillenia ovata extract exhibits potent antioxidant and hepatoprotective activities, highlighting its potential as a promising source of bioactive natural products.