Clinical phenotypes of motor neurone disease in a Kenyan hospital-based population

This Kenyan case series of MND patients demonstrated a higher rate of bulbar onset disease [<i>33.1, 95% CI (26.4-42.5%), p = 0.018</i>] in comparison to what has been demonstrated in other African studies. A finding that supports geographic variation in MND presentation and that emphasizes the need for region specific genetic studies.

Authors

Jasmit Shah (ORCID: https://orcid.org/0000-0002-7957-5426)
Dilraj Sokhi (ORCID: https://orcid.org/0000-0002-8819-0851)
Thomas M. Jenkins (ORCID: https://orcid.org/0000-0003-0342-7184)
Juzar Hooker (ORCID: https://orcid.org/0000-0001-7057-1843)
Effie Nailah Kamadi

Institutions

Curtin University (AU)
Aga Khan University Nairobi (KE)

Publication Details

Journal: Frontiers in Neurology
Published: 2025-12-03
DOI: https://doi.org/10.3389/fneur.2025.1662690
Primary Topic: Amyotrophic Lateral Sclerosis Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Clinical phenotypes of motor neurone disease in a Kenyan hospital-based population

Jasmit Shah, Dilraj Sokhi, Thomas M. Jenkins, Juzar Hooker et al.

Dec 3, 2025

Frontiers in Neurology

Amyotrophic Lateral Sclerosis Research

article

Clinical phenotypes of motor neurone disease in a Kenyan hospital-based population

Jasmit Shah, Dilraj Sokhi, Thomas M. Jenkins, Juzar Hooker, Effie Nailah Kamadi

December 3, 2025article en

Abstract

This Kenyan case series of MND patients demonstrated a higher rate of bulbar onset disease [<i>33.1, 95% CI (26.4-42.5%), p = 0.018</i>] in comparison to what has been demonstrated in other African studies. A finding that supports geographic variation in MND presentation and that emphasizes the need for region specific genetic studies.

Frontiers in NeurologyVol. 16

Curtin University (AU), Aga Khan University Nairobi (KE)

Openalex Percentile: Top 47%

Amyotrophic Lateral Sclerosis Research

DOI Open Access PDF OpenAlex

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