Endocytic Pathways and Actin Remodeling Mediate Everolimus-Induced VE-Cadherin Disorganization and Barrier Dysfunction
EVL compromises endothelial barrier integrity by promoting VE-cadherin internalization and lysosomal degradation, accompanied by cytoskeletal remodeling and a Golgi-dependent, partial restoration of junctional VE-cadherin. These findings highlight endocytic, degradative, and Golgi-mediated trafficking pathways as key modulators of EVL-induced endothelial barrier dysfunction and provide mechanistic insight into the vascular effects of rapalog-based mTOR inhibition.
Authors
- Kimberly M. Stroka (ORCID: https://orcid.org/0000-0003-3314-2067)
- Ken D. Brandon (ORCID: https://orcid.org/0009-0004-2244-2747)
- Yoshi Chettri (ORCID: https://orcid.org/0000-0003-1215-7673)
- Azkah Anjum
Institutions
- University of Maryland, Baltimore (US)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- University of Baltimore (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- Cellular and Molecular Bioengineering
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1007/s12195-025-00881-y
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences