Retinoic Acid Receptor-related Orphan Receptor α Drives Glucose Reprogramming and Mitochondrial Rescue Mitigate Subarachnoid Hemorrhage-Induced Early Brain Injury
We are the first to demonstrate that RORα activation reprogrammed neuronal glucose metabolism and strengthened antioxidant defenses to mitigate SAH-induced EBI. The targeting of RORα could represent a promising therapeutic strategy for stroke-related metabolic failure and oxidative stress. Future work should explore the translational potential in clinical settings. <i>Antioxid. Redox Signal.</i> 44, 275-291.
Authors
- Yichao Jin (ORCID: https://orcid.org/0000-0003-4141-7876)
- Jiaqi Wang (ORCID: https://orcid.org/0000-0003-4033-3398)
- Fengchen Zhang (ORCID: https://orcid.org/0009-0009-7826-7040)
- Jie Li (ORCID: https://orcid.org/0000-0002-4063-9381)
- Xiaohua Zhang (ORCID: https://orcid.org/0000-0001-9679-2767)
- Shiyu Guo (ORCID: https://orcid.org/0009-0008-0879-0517)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Guangzhou University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1177/15230864251399609
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00