Red blood cell transfusion exacerbates phlebotomy‐induced anemia‐associated neuroinflammation in murine neonates
We report that PIA causes early brain inflammation and RBCT leads to the recruitment of circulating monocytes to the anemic brain, thus contributing to a chronic hyperinflammatory response with transcriptional changes in genes associated with brain function.
Authors
- Mohan Kumar Krishnan (ORCID: https://orcid.org/0000-0003-1036-5188)
- Jennifer Raj (ORCID: https://orcid.org/0000-0002-8413-9995)
- Marie Amalie Balamurugan
- Balamurugan Ramatchandirin (ORCID: https://orcid.org/0000-0003-0390-1878)
- Suneetha Desiraju (ORCID: https://orcid.org/0000-0002-0634-4889)
- Eric S. Peeples (ORCID: https://orcid.org/0000-0002-2892-2678)
- Sean Fine (ORCID: https://orcid.org/0000-0002-3993-5773)
- Pramod Shrestha
- Arjun Subrramanya
Institutions
- Nebraska Medical Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- CHI Health (US)
- University of Nebraska Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Transfusion
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1111/trf.70018
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00