SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2025)

This guideline provides a comprehensive overview of the management of localized rectal cancer, highlighting recent major advances in therapeutic strategies. Accurate staging remains essential, as it informs treatment decisions and facilitates risk assessment. A pivotal development in rectal cancer treatment is the adoption of total neoadjuvant therapy (TNT), which has demonstrated improved tumor response, reduced risk of systemic recurrence, and enhanced survival outcomes. This approach enables a "watch-and-wait" strategy and conservative management that may render surgery unnecessary and preserves rectal function in patients who achieve a complete clinical response. By emphasizing a structured approach to staging, multidisciplinary evaluation, and innovative treatment pathways, this guideline aims to improve outcomes while minimizing the morbidity associated with rectal cancer treatment.

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Publication Details

Journal
Clinical & Translational Oncology
Published
2025-12-03
DOI
https://doi.org/10.1007/s12094-025-04140-4
Citations
1
Primary Topic
Colorectal Cancer Surgical Treatments
Type
article
Field-Weighted Citation Impact
1.05

Funders

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article

SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2025)

Vicente Alonso Orduña, Encarnación González‐Flores, Elena Asensio, R. Vidal Tocino et al.
1 citations
Clinical & Translational Oncology
Colorectal Cancer Surgical Treatments
1.05
article

SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2025)

Vicente Alonso Orduña, Encarnación González‐Flores, Elena Asensio, R. Vidal Tocino, F. Losa Gaspà, M.J. Safont Aguilera, María Luisa Limón Mirón, M. Martínez, José Luis Manzano Mozo, Ruth Vera García
article en
1 citations

Abstract

This guideline provides a comprehensive overview of the management of localized rectal cancer, highlighting recent major advances in therapeutic strategies. Accurate staging remains essential, as it informs treatment decisions and facilitates risk assessment. A pivotal development in rectal cancer treatment is the adoption of total neoadjuvant therapy (TNT), which has demonstrated improved tumor response, reduced risk of systemic recurrence, and enhanced survival outcomes. This approach enables a "watch-and-wait" strategy and conservative management that may render surgery unnecessary and preserves rectal function in patients who achieve a complete clinical response. By emphasizing a structured approach to staging, multidisciplinary evaluation, and innovative treatment pathways, this guideline aims to improve outcomes while minimizing the morbidity associated with rectal cancer treatment.

Clinical & Translational OncologyVol. 28(2)
Hospital Universitario 12 De Octubre (ES), Institut Català d'Oncologia (ES), Navarre Institute of Health Research (ES), Instituto de Investigación Biosanitaria de Granada (ES), Hospital Universitario Miguel Servet (ES), Hospital General Universitario de Elche (ES), Hospital Universitario Virgen de las Nieves (ES), Navarrabiomed (ES), Hospital General Universitario De Valencia (ES), Hospital de Sant Joan Despí Moisès Broggi (ES), Instituto de Investigación Biomédica de Salamanca (ES), Hospital Universitario Virgen del Rocío (ES)
Sociedad Española de Oncología Médica
Openalex Percentile: Top 15%
Colorectal Cancer Surgical Treatments
1.05
DOIOpen Access PDFOpenAlex
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