Dose threshold values for endovascular photodynamic therapy (PDT) in normal pig pancreas and human pancreatic cancer
These findings suggest that PDT can potentially create a margin around major pancreatic blood vessels free of viable tumour tissue. The calculated dosimetry supports the feasibility of clinical application using the proposed Verteporfin dose and light delivery parameters, warranting further investigation in Clinical trials.
Authors
- Lothar Lilge (ORCID: https://orcid.org/0000-0001-5533-0005)
- Fanélie Wanert (ORCID: https://orcid.org/0000-0002-8071-2109)
- Alain García Vázquez (ORCID: https://orcid.org/0000-0001-5859-2852)
- Axel Schmid (ORCID: https://orcid.org/0000-0001-6461-8705)
- Tina Saeidi
- Stephen G. Bown (ORCID: https://orcid.org/0000-0002-5538-9303)
- Lee L. Swanström (ORCID: https://orcid.org/0000-0002-1740-463X)
- Juan M. Verde (ORCID: https://orcid.org/0000-0002-9127-8467)
- Arjen Bogaards
- Irene Alexandra Spiridon
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- University of Johannesburg (ZA)
- Princess Margaret Cancer Centre (CA)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- BioDetection Systems (Netherlands) (NL)
- Universitätsklinikum Erlangen (DE)
- Institut de Chirurgie Guidée par l'Image (FR)
- University College London (GB)
Publication Details
- Journal
- Photochemical & Photobiological Sciences
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1007/s43630-025-00791-y
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Margaret Cancer Foundation
- Agence Nationale de la Recherche
- Ministero dello Sviluppo Economico