Implantable biosensors for continuous sepsis detection in postoperative care

Implantable biosensors are emerging as transformative tools for real-time sepsis surveillance in postoperative patients. By continuously monitoring key inflammatory biomarkers such as cytokines and endotoxins, these systems can enable earlier diagnosis and intervention than traditional intermittent testing. Technological advances such as active-reset DNA-aptamer biosensors for cytokine tracking and electrochemical lipopolysaccharide sensors achieving attogram-level sensitivity illustrate rapid progress in the field. Research across the United States, Europe, and Asia highlights the growing global commitment to integrating biosensors into perioperative monitoring. Their application across surgical specialties may fundamentally shift postoperative care from reactive to predictive management, reducing sepsis-related morbidity and mortality. Ongoing research into wireless communication, long-term biocompatibility, and multiplexed sensing will be pivotal to clinical translation and adoption in both high- and low-resource healthcare systems.