Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Pathogenicity
DIP ameliorated intraocular inflammation, modulated Th17/Treg balance, and reduced Th17 pathogenicity in EAU, potentially via cAMP-STAT3-PIM1 signaling. These findings highlight DIP as a promising therapeutic candidate for autoimmune uveitis.
Authors
- Wenru Su (ORCID: https://orcid.org/0000-0002-0506-6362)
- Binyao Chen
- Jianjie Lv (ORCID: https://orcid.org/0009-0003-4020-0883)
- Haotian Lin (ORCID: https://orcid.org/0000-0003-4672-9721)
- Yingying Wen (ORCID: https://orcid.org/0000-0003-4327-6368)
- Xulin Zhang (ORCID: https://orcid.org/0000-0003-3068-1276)
- Junjie Chen (ORCID: https://orcid.org/0000-0002-3046-4821)
- Xia Wu (ORCID: https://orcid.org/0009-0008-4912-6225)
- Zhaohao Huang (ORCID: https://orcid.org/0000-0002-6958-2673)
- Yi Wu
Institutions
- Sun Yat-sen University (CN)
- Bengbu Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Hainan Eye Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1167/iovs.66.15.16
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China