Targeting MCM6 Enhances Melphalan Chemosensitivity in Retinoblastoma by Modulating DNA Damage Response
MCM6 acts as a critical regulator of retinoblastoma growth and modulates response to melphalan. Targeting MCM6 may offer a therapeutic approach to improve outcomes of chemotherapy in retinoblastoma.
Authors
- Yang Gao (ORCID: https://orcid.org/0000-0002-9068-9993)
- Yaoming Liu (ORCID: https://orcid.org/0009-0001-5642-4422)
- Meng Wang (ORCID: https://orcid.org/0000-0002-5860-7206)
- Lijuan Tang (ORCID: https://orcid.org/0000-0002-1185-4912)
- Jinmiao Li (ORCID: https://orcid.org/0000-0002-5130-4616)
- Jianjie Lv (ORCID: https://orcid.org/0009-0003-4020-0883)
- Shuxia Chen (ORCID: https://orcid.org/0000-0002-3090-847X)
- Zhihui Zhang (ORCID: https://orcid.org/0000-0003-0635-6297)
- Ping Zhang (ORCID: https://orcid.org/0009-0007-4290-6934)
- Junjie Tang (ORCID: https://orcid.org/0000-0003-3185-9929)
- Rong Lu (ORCID: https://orcid.org/0000-0002-5716-6955)
- Hetian Sun
- Shicai Su
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1167/iovs.66.15.14
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Ophthalmology