Urine Olfactomedin 4 Predicts Furosemide Response and Kidney Replacement Therapy in Critically Ill Children
In critically ill children at high risk for AKI, both uOLFM4 and uNGAL have moderate discriminatory ability to predict furosemide responsiveness and KRT receipt on the first day of PICU stay. The NPV greater than or equal to 95% for uOLFM4 for both outcomes make it a promising candidate for implementation into clinical decision support to facilitate early KRT initiation decision-making.
Authors
- Stuart L. Goldstein (ORCID: https://orcid.org/0000-0003-3711-8785)
- Prasad Devarajan (ORCID: https://orcid.org/0000-0002-7847-8552)
- Denise Hasson (ORCID: https://orcid.org/0000-0001-6172-4756)
- Kristalynn M. Kempton (ORCID: https://orcid.org/0000-0001-7963-7458)
- AJ Bennett
- Stephen W. Standage (ORCID: https://orcid.org/0000-0002-0550-6532)
- Cheryl L. Sargel
- Jennifer A. Muszynski (ORCID: https://orcid.org/0000-0002-3329-8048)
- Kelli A. Krallman (ORCID: https://orcid.org/0000-0002-3275-2982)
- Matthew N. Alder (ORCID: https://orcid.org/0000-0003-2879-6576)
- Diana Zepeda‐Orozco (ORCID: https://orcid.org/0000-0003-0671-4453)
- Jeffrey Lutmer (ORCID: https://orcid.org/0000-0002-0604-2637)
- E Pascal (ORCID: https://orcid.org/0009-0002-6281-7772)
- Susan D. Martin
- Imogen Clover-Brown
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Nationwide Children's Hospital (US)
- NYU Langone Health (US)
- Golisano Children's Hospital (US)
- The Ohio State University (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/cce.0000000000001356
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00