Integrin α1β1 Promotes Interstitial Fibrosis and Cyst Growth in a Mouse Model of Polycystic Kidney Disease
These results highlight a previously unrecognized role for integrin- α 1 in cyst growth and fibrosis in PKD.
Authors
- Rachel Lennon (ORCID: https://orcid.org/0000-0001-6400-0227)
- Dorien J.M. Peters (ORCID: https://orcid.org/0000-0001-6974-7143)
- Richard W. Naylor (ORCID: https://orcid.org/0000-0003-2901-7677)
- Céline Grenier (ORCID: https://orcid.org/0000-0003-4521-9404)
- I‐Hsuan Lin (ORCID: https://orcid.org/0000-0002-6207-1299)
- Ambra Pozzi (ORCID: https://orcid.org/0000-0001-8502-1481)
Institutions
- Vanderbilt University (US)
- Leiden University Medical Center (NL)
- Wellcome Centre for Cell-Matrix Research (GB)
- University of Manchester (GB)
- Hypertension Institute (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2025-11-25
- DOI
- https://doi.org/10.1681/asn.0000000941
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00