Juvenile vs. adult skeletal muscle transplants in the treatment of volumetric muscle loss injury

Juvenile skeletal muscle displays cellular and structural attributes favorable for regeneration and superior in-vitro myogenic behavior compared to adult muscle. However, these advantages did not translate into greater short-term in-vivo recovery following VML transplantation. Enhancing donor fiber hypertrophy, neuromuscular integration, and satellite cell expansion beyond the transplant region, potentially through rehabilitation or pharmaceutical interventions, may be necessary to realize the full therapeutic potential of juvenile donor muscle for regenerative medicine applications.