Canagliflozin as a Potential Preclinical Therapy for Tuberous Sclerosis Complex: Inhibition of Tsc2−/− Cell Proliferation via Cell Cycle Arrest and Mitochondrial Dysfunction
Ca inhibits <i>Tsc2</i> <sup>-/-</sup> cell proliferation through dual mechanisms of cell cycle arrest and mitochondrial impairment, demonstrating significant therapeutic potential for TSC-related lesions. These findings highlight Ca as a promising alternative to current mTOR inhibitors, warranting further investigation into its molecular targets and clinical applications.
Authors
- Kai Zheng (ORCID: https://orcid.org/0000-0003-1353-7483)
- Qingyun Wei
- K. X. Su (ORCID: https://orcid.org/0000-0002-1965-6777)
- B. Liu (ORCID: https://orcid.org/0000-0002-2463-3457)
- Hongliang Gao (ORCID: https://orcid.org/0000-0002-8415-3738)
- Jing Wu (ORCID: https://orcid.org/0000-0002-9017-8405)
- Shuangchi Liu
- Xing Peng (ORCID: https://orcid.org/0009-0006-5173-8234)
- Yuqi Wang (ORCID: https://orcid.org/0000-0002-9793-6002)
- Juan Ye (ORCID: https://orcid.org/0000-0002-1948-2500)
- Tao Xu (ORCID: https://orcid.org/0000-0003-0153-0815)
- Liming Gou (ORCID: https://orcid.org/0000-0002-4551-975X)
- Yinjuan Zhao (ORCID: https://orcid.org/0000-0003-3457-9180)
- Xiaoxiao Dai (ORCID: https://orcid.org/0000-0002-5801-4814)
- Bin Xue (ORCID: https://orcid.org/0009-0007-9270-1072)
Institutions
- Wannan Medical College (CN)
- Nanjing University of Chinese Medicine (CN)
- Nanjing Forestry University (CN)
- Nanjing Children's Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s525749
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University
- Natural Science Foundation of Xinjiang