Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5
These findings suggest that KDM5 operates in conjunction with local chromatin contexts to employ demethylase-dependent and independent mechanisms of gene expression regulation in the brain. Disruption to this regulation affects pathways critical for neuronal function and is likely to contribute to the cognitive and behavioral features seen in patients.
Authors
- Matanel Yheskel (ORCID: https://orcid.org/0000-0002-0913-3569)
- Julie Secombe (ORCID: https://orcid.org/0000-0002-5826-7547)
- Melissa Castiglione (ORCID: https://orcid.org/0000-0002-1388-7654)
Institutions
- Albert Einstein College of Medicine (US)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s13072-025-00644-z
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Irma T. Hirschl Trust
- National Institutes of Health
- Intellectual and Developmental Disabilities Research Center