Efficacy and Safety of Dexmedetomidine Nasal Spray as a Premedication in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation: A Randomized Controlled Trial
Premedication with dexmedetomidine nasal spray in patients undergoing FB under sedation was associated with more effective suppression of procedure-induced cough, better hemodynamic stability, a lower incidence of PONV, and a faster recovery profile compared to both intranasal saline and lidocaine, without increasing respiratory depression. Consequently, dexmedetomidine nasal spray can effectively and safely enhance patient comfort and safety, and optimize the procedural conditions for the bronchoscopists.
Authors
- Guiqiu Zhao (ORCID: https://orcid.org/0000-0002-6804-6406)
- Jiangdong Wu (ORCID: https://orcid.org/0000-0002-4804-9706)
- Xueke Du (ORCID: https://orcid.org/0000-0001-9796-9202)
- H. Qiu (ORCID: https://orcid.org/0000-0002-9353-3222)
- Xiaoqing Jiang (ORCID: https://orcid.org/0000-0003-2102-4039)
- Lini Chen (ORCID: https://orcid.org/0009-0006-0995-3774)
- Shen-Qiao Wei
- Weiyong Qin
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s550551
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangxi Medical University