Cx43 hemichannel-mediated paracrine involves in the promotion of MSCs on skin wound healing
Our findings reveal a novel mechanism that MSCs promote wound healing through Cx43 hemichannel-mediated paracrine, mainly ATP secretion. MSC CM facilitates macrophage polarization, angiogenesis, and fibroblast migration, ultimately enhancing tissue repair. Our finding identifies a novel role for Cx43 hemichannels in the process that MSCs facilitate tissue repair and offer a promising therapeutic strategy in clinical applications to improve wound healing.
Authors
- Xiangya Dou
- Huiyun Xu (ORCID: https://orcid.org/0000-0002-4873-9934)
- Xue-Zhou Yang
- Dong‐En Wang (ORCID: https://orcid.org/0000-0003-0419-3164)
- Yaping Zhang (ORCID: https://orcid.org/0000-0002-9264-3120)
- Yinbo Niu
Institutions
- Northwestern Polytechnical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1186/s13287-025-04796-3
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- National Natural Science Foundation of China