T-Cell Interferon Gamma Responses to SARS-CoV-2 Following Infection with/Without Vaccination in a Tanzanian Population
Strong and possibly cross-reactive T-cell responses to SARS-CoV-2 were detected in Tanzanian individuals following infection with/without vaccination. Moreover, high plasma IFN-γ levels were detected, especially among participants who consumed alcohol. We recommend for modifications of the ELISpot T-cell assays to optimize the evaluation of pathogen-specific T-cell responses among African residents given the high background IFN-γ release.
Authors
- Mark M. Ndubi (ORCID: https://orcid.org/0000-0001-7030-2678)
- Emmanuel Balandya (ORCID: https://orcid.org/0000-0002-3707-9985)
- Mbazi Senkoro
- Furaha Lyamuya (ORCID: https://orcid.org/0000-0002-0136-2826)
- Sayoki Mfinanga (ORCID: https://orcid.org/0000-0001-9067-2684)
- Frank E. Hassan
- Lilian Nkinda (ORCID: https://orcid.org/0000-0002-6252-9749)
- Godfrey Barabona (ORCID: https://orcid.org/0009-0005-6215-7737)
- Elisha Osati (ORCID: https://orcid.org/0000-0003-1192-4148)
- Emmanuel James Nkuwi (ORCID: https://orcid.org/0000-0001-8680-3637)
- Chihiro Motozono (ORCID: https://orcid.org/0000-0002-9027-742X)
- Frank Msafiri (ORCID: https://orcid.org/0000-0003-0450-1147)
- Takamasa Ueno (ORCID: https://orcid.org/0000-0003-4852-4236)
- Harrison Chuwa (ORCID: https://orcid.org/0000-0002-7632-9051)
- Benson R. Kidenya (ORCID: https://orcid.org/0000-0001-6056-4156)
- Doreen Kamori (ORCID: https://orcid.org/0000-0001-5162-6554)
- Juma Kisuse
- Posian Kunambi
Institutions
- Muhimbili University of Health and Allied Sciences (TZ)
- Catholic University of Health and Allied Sciences (TZ)
- Aga Khan Hospital Dar es Salaam (TZ)
- The University of Dodoma (TZ)
- Management and Development for Health (TZ)
- Muhimbili National Hospital (TZ)
- Kumamoto University (JP)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s532514
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of the United Kingdom
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- Japan Society for the Promotion of Science
- European and Developing Countries Clinical Trials Partnership