Seven days of strength training reprograms hydroxymethylation in the visceral adipose tissue of obese Swiss mice
Short-term strength training promotes a reduction in the mass of subcutaneous and visceral adipose tissues. Obesity increased DNA demethylation, demonstrated by increased Nfkb gene expression and protein levels in mesenteric adipose tissue. Exercise has the potential to induce epigenetic modifications, such as interrupting DNA demethylation in mesenteric adipocytes. Short-term strength training alters the specific genomic region controlling NFκB transcription in the context of pre-existing obesity.
Authors
- Leandro Pereira de Moura (ORCID: https://orcid.org/0000-0003-3211-1058)
- Célio Júnior da Costa Fernandes (ORCID: https://orcid.org/0000-0003-1009-3127)
- Vívian Cristina da Cruz Rodrigues (ORCID: https://orcid.org/0000-0001-9622-652X)
- Diego Gomes de Melo (ORCID: https://orcid.org/0000-0002-1238-2494)
- Thaís Dantis Pereira de Campos (ORCID: https://orcid.org/0000-0002-9426-874X)
- Raphael dos Santos Canciglieri (ORCID: https://orcid.org/0000-0001-7974-1757)
- Gustavo José de Sá Pereira (ORCID: https://orcid.org/0000-0003-3941-5126)
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Journal of Endocrinology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1530/joe-25-0283
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00