Chinese expert consensus on intranasal anticholinergics for allergic rhinitis
Allergic rhinitis (AR) is a prevalent inflammatory condition of the nasal mucosa, characterized by rhinorrhea, nasal congestion, sneezing, and itching. Among these symptoms, rhinorrhea and nasal congestion are the most common complaints of AR patients. By blocking acetylcholine binding with muscarinic (M) receptors, intranasal anticholinergics have been recommended by guidelines as an "add-on" or second-line therapy to control rhinorrhea in patients with AR. Bencycloquidium bromide is a highly selective M1/M3 receptor antagonist that can reduce excessive mucus secretion and suppress type 2 inflammation in AR, while also demonstrating efficacy in alleviating overall nasal symptoms. In this consensus, we systematically review the role of acetylcholine and M receptors in AR pathogenesis, the key findings from clinical trials on intranasal anticholinergics for AR management and the evidence-based recommendations from experts in Allergy and Rhinology, hoping to guide physicians in the standardized and precise use of intranasal anticholinergics for AR patients.
Authors
- Meiping Lu (ORCID: https://orcid.org/0000-0001-8097-614X)
- Hongmeng Yu (ORCID: https://orcid.org/0000-0002-2578-9103)
- Qianhui Qiu (ORCID: https://orcid.org/0000-0001-6335-5173)
- Chengshuo Wang (ORCID: https://orcid.org/0000-0003-0646-5135)
- Jianfeng Liu (ORCID: https://orcid.org/0000-0002-5502-0872)
- Qintai Yang (ORCID: https://orcid.org/0000-0003-3377-737X)
- Luo Zhang (ORCID: https://orcid.org/0000-0002-0910-9884)
- Jiao Xia
- Dongdong Zhu (ORCID: https://orcid.org/0000-0002-8495-5626)
- Jing Ye (ORCID: https://orcid.org/0000-0002-9471-3321)
- Huanhai Liu (ORCID: https://orcid.org/0000-0001-9756-7588)
- Yu Xu (ORCID: https://orcid.org/0000-0001-7751-6345)
- Yana Zhang (ORCID: https://orcid.org/0000-0003-0405-2943)
- Yuanteng Xu (ORCID: https://orcid.org/0000-0001-9260-1417)
- Xueyan Wang (ORCID: https://orcid.org/0000-0001-9973-540X)
- Xiangdong Wang (ORCID: https://orcid.org/0000-0002-6462-4512)
- Jian Li (ORCID: https://orcid.org/0000-0001-7953-8230)
- Jianjun Chen (ORCID: https://orcid.org/0000-0002-8631-4558)
- Zheng Liu (ORCID: https://orcid.org/0000-0002-4168-6702)
- Xian Li (ORCID: https://orcid.org/0009-0002-8129-3812)
- Yuan Zhang (ORCID: https://orcid.org/0000-0003-1080-4267)
- Lei Cheng (ORCID: https://orcid.org/0000-0001-6541-7702)
- Hao Tian (ORCID: https://orcid.org/0000-0002-8606-6806)
- Yue Zhou (ORCID: https://orcid.org/0000-0002-0370-5116)
- Tingting Ma (ORCID: https://orcid.org/0000-0002-8488-651X)
- Wei Lv (ORCID: https://orcid.org/0000-0002-8945-7693)
- Yu-Cheng Yang
Institutions
- Beijing Tongren Hospital (CN)
- Fujian Medical University (CN)
- Union Hospital (HK)
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Jilin University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Wuhan University (CN)
- Shanghai Changzheng Hospital (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Beijing Municipal Education Commission (CN)
- Guangdong Academy of Medical Sciences (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Beijing Friendship Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Beijing Shijitan Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Nanjing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Asia Pacific Allergy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.5415/apallergy.0000000000000243
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00