Cerebral blood flow in a tri-ethnic population: insights from pCASL perfusion MRI
Question Prevalence and distribution of arterial transit artefacts (ATAs) on arterial spin labelling MRI, and their relationship to sex, ethnicity, vascular anatomy, and cardiovascular parameters, have not been systematically investigated. Findings ATAs were most prevalent in African Caribbeans, particularly in MCA-PCA borderzones and PCA territories; no significant differences were found between White Europeans and South Asians. Clinical relevance Visual rating revealed substantial differences in the ATA distribution among ethnic populations, as well as between women and men. Recognising these specific patterns can help distinguish physiological from pathological perfusion, thereby enhancing diagnostic accuracy and treatment planning.
Authors
- Magdalena Sokolska (ORCID: https://orcid.org/0000-0003-1715-5263)
- Therese Tillin (ORCID: https://orcid.org/0000-0003-1590-9826)
- David Atkinson (ORCID: https://orcid.org/0000-0003-1124-6666)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- Rafael Rehwald (ORCID: https://orcid.org/0000-0003-4357-3581)
- Hans Rolf Jäger (ORCID: https://orcid.org/0000-0002-6403-4184)
- Alun David Hughes (ORCID: https://orcid.org/0000-0001-5432-5271)
- Nish Chaturvedi (ORCID: https://orcid.org/0000-0002-6211-2775)
- Lorna Smith (ORCID: https://orcid.org/0000-0002-1454-0732)
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- Physiological Society (GB)
- King's College School (GB)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- European Radiology
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1007/s00330-025-12160-5
- Citations
- 1
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Wellcome Trust
- British Heart Foundation
- Diabetes UK