Flow cytometric identification of dynamic immune cell populations in a rat model of post-traumatic elbow contracture
A method for flow cytometry on rat elbow capsule was established and used to quantify immune cell populations, which changed in response to injury and anti-inflammatory treatment. Comparisons between flow cytometry and previously published mechanics and histology revealed additional insights about temporal patterns in cell-, tissue-, and joint-level changes. Future work will investigate whether changes in immune cells attenuate PTJC symptoms.
Authors
- Matthew R. Bersi (ORCID: https://orcid.org/0000-0003-1848-4165)
- Paul C. Cannon (ORCID: https://orcid.org/0000-0002-8509-3845)
- Spencer P. Lake (ORCID: https://orcid.org/0000-0002-7424-947X)
- Aaron M. Chamberlain (ORCID: https://orcid.org/0000-0002-4622-9797)
- Chelsey L. Dunham (ORCID: https://orcid.org/0000-0002-8827-5257)
- Necat Havlioglu
- Ryan M. Castile (ORCID: https://orcid.org/0000-0002-1974-2106)
- J. Caleb Snider (ORCID: https://orcid.org/0000-0003-3568-381X)
- Rebecca F. Reals (ORCID: https://orcid.org/0000-0002-5233-9888)
- Benjamin M. Zmistowski
Institutions
- Intermountain Healthcare (US)
- National Institutes of Health (US)
- Washington University in St. Louis (US)
- John Cochran VA Medical Center (US)
- Brigham Young University - Idaho (US)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2025-12-03
- DOI
- https://doi.org/10.1080/03008207.2025.2593877
- Primary Topic
- Elbow and Forearm Trauma Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00